Last updated: 2024-07-23

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Knit directory: DOX_24_Github/

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Research website for the project “DNA damage-associated protein co-expression networks in cardiomyocytes provide insight into tolerance to genetic variation and cardiovascular disease”

Preprocessing and comparison of protein acqustion types

Unwanted tehnical variation removal and differential abundance testing

Data independent acquisition (DIA) vs dependent acquiston (DDA) protein abundance and DOX responses

Main Figures & additional analyses

Figure 1: DOX-treated iPSC-CMs cluster by treatment and most closely resemble the heart ventricle proteome.

Figure 2: Network analysis of the iPSC-CM proteome identifies protein co-expression modules correlated with DOX treatment.

Figure 3: Network modules display heterogeneity for cellular localization and tissue specificity.

Figure 4: DOX-correlated module proteins are enriched for distinct functions.

Figure 5: DOX-correlated hub proteins are depleted for protein quantitative trait loci.

Figure 6: DOX-correlated hub proteins are enriched for loss-of-function intolerant proteins.

Figure 7: DOX-correlated modules are enriched for proteins mapped to cardiovascular traits and diseases.

Figure 8: DOX-correlated hub proteins are enriched for physical protein interactors of CVD risk proteins.